San Francisco 49ers (-5.5) vs. Indianapolis Colts [Total: 46] Game Overview An interconference matchup between two teams trending in very different directions caps off the Week 16 slate. In an ultra-competitive NFC West, the 49ers have been surging at the right time, having won (and covered) each of their past four games. Not only does … Continue reading "49ers-Colts Week 16 Monday Night Football Preview: Odds, lines, best bets"
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